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The Big Bang Theory is a CBS sitcom, from Two and a Half Men's creator Chuck Lorre, about two brilliant physicists (Johnny Galecki - Roseanne & Jim Parsons), but none of that genius helps them interact with people, especially women. This begins to change when a free-spirited beauty named Penny (Kaley Cuoco - 8 Simple Rules) moves in next door, Sara Gilbert (Roseanne) will guest star.