Does Sheldon have Asperger's Syndrome? in The Show Posted March 31, 2008 One of the reasons why I love this show so much is because Sheldon reminds me so much of my 9-year-old son. He's like the grown-up version of my son, who has Asperger's. The mannerisms, social clueless-ness, inability to lie, lack of eye contact, ect... It is refreshing to see it put in a comical light on TV like that. As an ESE teacher, I picked up on the obvious Asperger's-like mannerims and personality, too. I bet that's not what they were going to on a true comedic tv show, but to those who know, Sheldon's Asperger's is obvious.