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Season 6, Episode 3 - Passion's Harvest and a Sheldocracy Airs October 13 at 8:00/7:00c on CBS Sheldon must choose sides in an ethical dilemma. Also, Mary tries her hand at writing and Mandy needs a new place to live.

Season 6, Episode 2 - Future Worf and the Margarita of the South Pacific Airs October 6, 2022 at 8:00/7:00c on CBS Sheldon and Missy try to help the family’s finances. Also, Mary struggles to find her footing without the church. Ed Begley, Jr., Melissa Peterman and Dan Byrd guest star.

Season 6, Episode 1 - Four Hundred Cartons of Undeclared Cigarettes and a Niblingo Airs September 29, 2022 at 8:00/7:00c on CBS George Sr. bails Meemaw and Georgie out of jail. Also, Sheldon and Missy meet Mandy (Emily Osment), and Mary feels unwelcome at church. Craig T. Nelson and Emily Osment guest star.

Season 5, Episode 22 - A Clogged Pore, a Little Spanish and the Future Airs May 19, 2022 at 8:00/7:00c on CBS Sheldon struggles to cope with the first signs of puberty. Also, Mary and George Sr. hunt for new jobs, and Georgie and Meemaw take a business trip across the border, on the fifth season finale of YOUNG SHELDON. Ed Begley, Jr. (Dr. Linkletter), Melissa Peterman (Brenda), Doc Farrow (Coach Wilkins), Rex Linn (Principal Petersen) and Wendie Malick (President Hagemeyer) all reprise their roles in the episode. Magicians Penn Jillette and Teller guest star in the episode.

Season 5, Episode 21 - White Trash, Holy Rollers and Punching People Airs May 12, 2022 at 8:00/7:00c on CBS As the church congregation gossips about Georgie, Missy stands up for her brother, and Sheldon is distracted by the family drama.

Season 5, Episode 20 - Uncle Sheldon and a Hormonal Firecracker Airs April 28, 2022 at 8:00/7:00c on CBS Sheldon and Missy learn about Georgie's pregnancy, and the whole family promises to keep it a secret. Matt Hobby (Pastor Jeff), Ed Begley, Jr. (Dr. Linkletter), Dan Byrd (Pastor Rob), Doc Farrow (Coach Wilkins) and Grady Lee Richmond (Wade) all reprise their roles in the episode.

Season 5, Episode 19 - A God-Fearin' Baptist and a Hot Trophy Husband Airs April 21, 2022 at 8:00/7:00c on CBS George and Mary insist on meeting the new woman in Georgie's life. Also, Sheldon and Missy have suspicions about what's going on with their family. Melissa Peterman, Wyatt McClure and Emily Osment return in the episode.

Season 5, Episode 18 - Babies, Lies and a Resplendent Cannoli Airs April 14, 2022 at 8:00/7:00c on CBS Sheldon copes with the death of a hero. Also, Missy wants to babysit, and Georgie struggles with his big secret. Wallace Shawn (Dr. Sturgis), Ed Begley, Jr. (Dr. Linkletter), Craig T. Nelson (Dale) and Emily Osment (Mandy) guest star in the episode.

Season 5, Episode 17 - A Solo Peanut, a Social Butterfly and the Truth Airs March 31, 2022 at 8:00/7:00c on CBS Sheldon gets an odd request from an old friend, Paige (McKenna Grace). Also, George Sr. and Mary are caught in the middle of Meemaw and Dale's breakup, and Georgie comes clean to Mandy. Craig T. Nelson (Dale), McKenna Grace (Paige) and Emily Osment (Mandy) guest star in the episode.

Season 5, Episode 15 - A Lobster, an Armadillo and a Way Bigger Number Airs March 3, 2022 at 8:00/7:00c on CBS Sheldon joins Dr. Linkletter (Ed Begley, Jr.) and Dr. Sturgis (Wallace Shawn) on a science road trip. Also, Georgie continues to lie about his age. Ming-Na Wen (E.R., The Book of Boba Fett) guest stars in this episode as Dr. Lee. Wallace Shawn, Ed Begley, Jr. and Wendie Malick return.

Season 5, Episode 14 - A Free Scratcher and Feminine Wiles Airs February 24, 2022 at 8:00/7:00c on CBS Sheldon butts heads with Dr. Lee (Ming-Na Wen), a new scientist in the lab. Also, Mary is given a lotto ticket. Ming-Na Wen (The Book of Boba Fett) guest stars. Wallace Shawn, Ed Begley, Jr. and Wendie Malick return.

Season 5, Episode 12 - A Pink Cadillac and a Glorious Tribal Dance Airs January 20, 2022 at 8:00/7:00c on CBS Sheldon attends his first comic book convention. Also, Mary tries selling make-up. Jason Alexander and Wendie Malick return as Gene Lundy and Professer Hagemeyer, respectively.

Season 5, Episode 10 - An Expensive Glitch and a Goof-Off Room Airs January 6, 2022 at 8:00/7:00c on CBS Sheldon gets a dorm room all to himself. Also, Meemaw gains an unwanted business partner. Wallace Shawn, Reba McEntire and Wendie Malick return as Dr. Sturgis, June and Professor Hagemeyer, respectively, in the episode.

Season 5, Episode 9 - The Yips and an Oddly Hypnotic Bohemian Airs December 9, 2021 at 8:00/7:00c on CBS Sheldon gets the science yips and has to learn how to not think. Also, George Sr. plays handyman at Brenda Sparks' house. Melissa Peterman and Wyatt McClure guest star.

Season 5, Episode 8 - The Grand Chancellor and a Den of Sin Airs December 2, 2021 at 8:00/7:00c on CBS Sheldon battles President Hagemeyer's (Wendie Malick) mysterious boss over the university's science requirements. Also, Mary discovers that Georgie is working at Meemaw's illegal gambling room. Wendie Malick and Ed Begley, Jr. guest star.

Season 5, Episode 7 - An Introduction to Engineering and a Glob of Hair Gel Airs November 18, 2021 at 8:00/7:00c on CBS Sheldon takes his first engineering class with Professor Boucher (Lance Reddick). Also, Meemaw and Dale help take care of his ex-wife, June (Reba McEntire). Lance Reddick (The Wire, Fringe) guest stars. Reba McEntire, Craig T. Nelson and Wendie Malick return.

Season 5, Episode 6 - Money Laundering and a Cascade of Hormones Airs November 11, 2021 at 8:00/7:00c on CBS Missy asks some uncomfortable questions at church, and Meemaw and Georgie go into business together. Wallace Shawn and Craig T. Nelson guest star.

Season 5, Episode 4 - Pish Posh and a Secret Back Room Airs October 28, 2021 at 8:00/7:00c on CBS Sheldon, Missy and Georgie adapt to new living arrangements. Also, Meemaw opens a gambling room. Craig T. Nelson guest stars.

Season 5, Episode 3 - Potential Energy and Hooch on a Park Bench Airs October 21, 2021 at 8:00/7:00c on CBS Sheldon tries to convince Dr. Sturgis to return to the university. Also, Georgie upsets the family when he makes a life-changing decision. Wallace Shawn, Ed Begley, Jr. and Craig T. Nelson guest star.

Season 5, Episode 2 - Snoopin' Around and the Wonder Twins of Atheism Airs October 14, 2021 at 8:00/7:00c on CBS Sheldon encourages Missy to question the Bible. Also, Meemaw is determined to catch George Sr. in a lie, and Mary helps Pastor Jeff (Matt Hobby) search for a youth pastor. Melissa Peterman guest stars.

Season 5, Episode 1 - One Bad Night and Chaos of Selfish Desires Airs October 7, 2021 at 8:00/7:00c on CBS Sheldon and Missy both run away from home, and Mary gets upsetting news about George Sr. Wallace Shawn and Melissa Peterman guest star.

Season 4, Episode 18 - The Wild and Woolly World of Nonlinear Dynamics Airs May 13, 2021 at 8:00/7:00c on CBS Missy's first heartbreak triggers a series of events that lead the Cooper family to the brink. Melissa Peterman guest stars.

Season 4, Episode 17 - A Black Hole Airs May 6, 2021 at 8:00/7:00c on CBS The Coopers discuss the possibilities of black holes and alternate universes when Dr. Sturgis comes over for dinner. Wallace Shawn and Wendie Malick guest star.

Season 4, Episode 16 - A Second Prodigy and the Hottest Tips for Pouty Lips Airs April 29, 2021 at 8:00/7:00c on CBS Sheldon finds himself at odds with Paige (Mckenna Grace) once again when she considers enrolling at East Texas Tech. Also, Mary seeks June’s (Reba McEntire) advice when looking for a change.

Season 4, Episode 14 - Mitch's Son and the Unconditional Approval of a Government Agency Airs April 15, 2021 at 8:00/7:00c on CBS When the IRS accuses Sheldon of making a mistake, he’ll stop at nothing to prove them wrong. Also, Dale is forced to get a colonoscopy and tries to convince Meemaw to join him.