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'The Wedding Gift Wormhole' - Season 12, Episode 2 Airs Thursday, September 27 at 8/7c on CBS. Sheldon and Amy drive themselves crazy trying to figure out what "perfect gift" Leonard and Penny gave them for their wedding. Also, Koothrappali decides he wants to settle down and asks his father to arrange a marriage for him. Brian George (Dr. Koothrappali), Brian Posehn (Bert) and Lauren Lapkus (Denise) guest star in the episode.

'The Conjugal Configuration' - Season 12, Episode 1 Airs Monday, September 24 at 8/7c on CBS. Sheldon and Amy's honeymoon runs aground in New York, while Penny and Leonard discover they are uncomfortably similar to Amy's parents, Mr. and Mrs. Fowler. Also, Koothrappali insults physicist Neil deGrasse Tyson and starts a Twitter war.

Season 1, Episode 22 - Vanilla Ice Cream, Gentlemen Callers, and a Dinette Set Airs May 10, 2018 at 8:30/7:30c on CBS When Meemaw is pursued by two gentlemen callers, Sheldon interferes, forcing her to set some ground rules. Wallace Shawn (The Princess Bride) and Richard Kind (Spin City) guest star.

Season 1, Episode 21 - Summer Sausage, a Pocket Poncho, and Tony Danza Airs May 3, 2018 at 8:30/7:30c on CBS While Sheldon is busy keeping tabs on Meemaw’s budding relationship with Dr. Sturgis, George Sr. and Mary attempt to bond with their other children. Wallace Shawn returns as Dr. John Sturgis.

'The Bow Tie Asymmetry' - Season 11, Episode 24 Airs Thursday, May 10 at 8/7c on CBS. When Amy's parents and Sheldon's family arrive for the wedding, everybody is focused on making sure all goes according to plan - everyone except the bride and groom. Kathy Bates, Mark Hamill, Teller, Laurie Metcalf, John Ross Bowie, Wil Wheaton, Brian Posehn, Jerry O'Connell, Courtney Henggeler and Lauren Lapkus guest star.

'The Sibling Realignment' - Season 11, Episode 23 Airs Thursday, May 3 at 8/7c on CBS. When Sheldon learns that his mother won't attend his wedding unless he invites his brother, Georgie (Jerry O'Connell), he and Leonard travel to Texas to end a family feud. Also, the Wolowitz kids inadvertently infest Amy, Bernadette, Wolowitz and Koothrappali with pinkeye.

Season 1, Episode 20 - A Dog, a Squirrel, and a Fish Named Fish Airs April 26, 2018 at 8:30/7:30c on CBS A battle erupts between the Coopers and Sparks when the Sparks’ new dog terrorizes Sheldon. Billy Gardell (Herschel Sparks), Melissa Peterman (Brenda Sparks) and Wyatt McClure (Billy Sparks) return in the episode.

Season 1, Episode 19 - Gluons, Guacamole, and the Color Purple Airs April 19, 2018 at 8:30/7:30c on CBS When Sheldon is no longer academically challenged at Medford High, he audits a college class taught by Dr. John Sturgis. Wallace Shawn (The Princess Bride, Toy Story) guest stars.

'The Monetary Insufficiency' - Season 11, Episode 22 Airs Thursday, April 26 at 8/7c on CBS. Sheldon goes to Vegas to win money for science. Also, Penny and Bernadette take Amy wedding dress shopping, but her terrible choice entangles them in a web of lies. Joshua Malina returns as President Siebert in this episode.

'The Comet Polarization' - Season 11, Episode 21 Airs Thursday, April 19 at 8/7c on CBS. Sheldon's comic book store experiences changes when writer Neil Gaiman puts Stuart's store on the map. Also, Koothrappali takes credit for Penny's astronomical discovery, and friendships are threatened.

'The Reclusive Potential' - Season 11, Episode 20 Airs Thursday, April 12 at 8/7c on CBS. A brilliant but reclusive scientist, Doctor Wolcott, invites Sheldon to his cabin in the middle of nowhere, and Leonard, Raj and Howard go along for the trip. Also, Penny and Bernadette improvise after Amy doesn't like the tame bachelorette party they planned for her. Peter MacNicol (Ally McBeal, Numbers) guest stars.

Season 1, Episode 17 - Jiu-jitsu, Bubble Wrap, and Yoo-hoo Airs April 5, 2018 at 8:30/7:30c on CBS Sheldon is bullied by an unlikely character, and Mary and George disagree on how to handle the situation. Billy Gardell (Mike & Molly) reprises his role as Herschel Sparks.

Season 1, Episode 16 - Killer Asteroids, Oklahoma, and a Frizzy Hair Machine Airs March 29, 2018 at 8:30/7:30c on CBS A disappointing loss at the science fair sends Sheldon's life in a new direction. Jason Alexander (Seinfeld) guest stars in the episode.

'The Gates Excitation' - Season 11, Episode 18 Airs Thursday, March 29 at 8/7c on CBS. Penny gets the opportunity to host Bill Gates at work when his company wants to partner with her pharmaceutical company. Also, Leonard, Koothrappali and Wolowitz do everything in their power to meet him, while Sheldon thinks he is the victim of an April Fools prank. Microsoft co-founder Bill Gates guest stars as himself.

'The Athenaeum Allocation' - Season 11, Episode 17 Airs Thursday, March 8 at 8/7c on CBS. Leonard jumps through hoops to help secure the perfect wedding venue for Sheldon and Amy. Also, Bernadette and Wolowitz have a hard time deciding who should stay at home with the kids and who should go back to work.

'The Novelization Correlation' - Season 11, Episode 15 Airs Thursday, February 1 at 8/7c on CBS. When Sheldon petitions Wil Wheaton to appear on the new Professor Proton show, Wil offers a role to Amy instead. Also, Penny gets angry when she thinks the female protagonist in Leonard's novel is based on her. Christine Baranski and Wil Wheaton guest star.

'The Separation Triangulation' - Season 11, Episode 14 Airs Thursday, January 18 at 8/7c on CBS. Koothrappali finds himself in the middle of domestic drama when he learns the woman he's dating, Nell (Beth Behrs), has a very upset husband, Oliver (Walter Goggins). Also, when Sheldon rents his old room back for a quiet place to work, he drives Leonard crazy by being a model tenant.

Season 1, Episode 11 - Demons, Sunday School, and Prime Numbers Airs January 11, 2018 at 8:30/7:30c on CBS A worried Mary sends Sheldon to Sunday school after she finds him playing Dungeons and Dragons with his friends Tam and Billy. Billy Gardell (Mike & Molly) guest stars.

'The Solo Oscillation' - Season 11, Episode 13 Airs Thursday, January 11 at 8/7c on CBS. When Sheldon kicks Amy out to work solo, she and Leonard bond during a series of science experiments. Also, Bert the geologist replaces Wolowitz in the band Footprints on the Moon, and Sheldon finds Penny a surprising source of scientific inspiration.

'The Confidence Erosion' - Season 11, Episode 10 Airs Thursday, December 7 at 8/7c on CBS. Sheldon and Amy try to eliminate stress from wedding planning by applying math to the process. Also, Koothrappali "breaks up" with Wolowitz after realizing his best friend is actually hurting his confidence.

'The Bitcoin Entanglement' - Season 11, Episode 9 Airs Thursday, November 30 at 8/7c on CBS. Sheldon tries to teach the guys a lesson after they cut him out of a potentially valuable Bitcoin investment. Also, a seven-year-old video reveals a secret about Leonard and Penny's relationship.

'The Tesla Recoil' - Season 11, Episode 8 Airs Thursday, November 16 at 8/7c on CBS. Leonard and Wolowitz are furious after they learn Sheldon went to work with the military behind their backs. Also, while Bernadette is on bed rest, she asks Raj to do some digging when she suspects Ruchi is trying to steal her job.

'The Geology Methodology' - Season 11, Episode 7 Airs Thursday, November 9 at 8/7c on CBS. Sheldon and Bert collaborate on a research project, despite Sheldon's embarrassment. Also, Penny and Bernadette coach Koothrappali on how to navigate his relationship with Ruchi.

'The Proton Regeneration' - Season 11, Episode 6 Airs Thursday, November 2 at 8/7c on CBS. Sheldon goes head-to-head with Wil Wheaton for the role of the new Professor Proton. Also, Penny steps in to take care of Halley when Bernadette and Wolowitz both wind up on bed rest.

Season 1, Episode 3 - Poker, Faith, and Eggs Airs November 9, 2017 at 8:30/7:30c on CBS When George Sr. is rushed to the emergency room, Meemaw comes to babysit, and the kids have an adventure getting to the hospital on their own. Vernee Watson, who has appeared on The Big Bang Theory as nurse Althea in five episodes, guest stars in this episode as Nurse Robinson.