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Season 5, Episode 2 - Snoopin' Around and the Wonder Twins of Atheism Airs October 14, 2021 at 8:00/7:00c on CBS Sheldon encourages Missy to question the Bible. Also, Meemaw is determined to catch George Sr. in a lie, and Mary helps Pastor Jeff (Matt Hobby) search for a youth pastor. Melissa Peterman guest stars.

Season 5, Episode 12 - A Pink Cadillac and a Glorious Tribal Dance Airs January 20, 2022 at 8:00/7:00c on CBS Sheldon attends his first comic book convention. Also, Mary tries selling make-up. Jason Alexander and Wendie Malick return as Gene Lundy and Professer Hagemeyer, respectively.

'The Bow Tie Asymmetry' - Season 11, Episode 24 Airs Thursday, May 10 at 8/7c on CBS. When Amy's parents and Sheldon's family arrive for the wedding, everybody is focused on making sure all goes according to plan - everyone except the bride and groom. Kathy Bates, Mark Hamill, Teller, Laurie Metcalf, John Ross Bowie, Wil Wheaton, Brian Posehn, Jerry O'Connell, Courtney Henggeler and Lauren Lapkus guest star.

Season 5, Episode 10 - An Expensive Glitch and a Goof-Off Room Airs January 6, 2022 at 8:00/7:00c on CBS Sheldon gets a dorm room all to himself. Also, Meemaw gains an unwanted business partner. Wallace Shawn, Reba McEntire and Wendie Malick return as Dr. Sturgis, June and Professor Hagemeyer, respectively, in the episode.

Season 5, Episode 9 - The Yips and an Oddly Hypnotic Bohemian Airs December 9, 2021 at 8:00/7:00c on CBS Sheldon gets the science yips and has to learn how to not think. Also, George Sr. plays handyman at Brenda Sparks' house. Melissa Peterman and Wyatt McClure guest star.

Season 5, Episode 8 - The Grand Chancellor and a Den of Sin Airs December 2, 2021 at 8:00/7:00c on CBS Sheldon battles President Hagemeyer's (Wendie Malick) mysterious boss over the university's science requirements. Also, Mary discovers that Georgie is working at Meemaw's illegal gambling room. Wendie Malick and Ed Begley, Jr. guest star.

Season 5, Episode 7 - An Introduction to Engineering and a Glob of Hair Gel Airs November 18, 2021 at 8:00/7:00c on CBS Sheldon takes his first engineering class with Professor Boucher (Lance Reddick). Also, Meemaw and Dale help take care of his ex-wife, June (Reba McEntire). Lance Reddick (The Wire, Fringe) guest stars. Reba McEntire, Craig T. Nelson and Wendie Malick return.

Season 5, Episode 6 - Money Laundering and a Cascade of Hormones Airs November 11, 2021 at 8:00/7:00c on CBS Missy asks some uncomfortable questions at church, and Meemaw and Georgie go into business together. Wallace Shawn and Craig T. Nelson guest star.

Season 5, Episode 4 - Pish Posh and a Secret Back Room Airs October 28, 2021 at 8:00/7:00c on CBS Sheldon, Missy and Georgie adapt to new living arrangements. Also, Meemaw opens a gambling room. Craig T. Nelson guest stars.

Season 5, Episode 3 - Potential Energy and Hooch on a Park Bench Airs October 21, 2021 at 8:00/7:00c on CBS Sheldon tries to convince Dr. Sturgis to return to the university. Also, Georgie upsets the family when he makes a life-changing decision. Wallace Shawn, Ed Begley, Jr. and Craig T. Nelson guest star.

Season 4, Episode 18 - The Wild and Woolly World of Nonlinear Dynamics Airs May 13, 2021 at 8:00/7:00c on CBS Missy's first heartbreak triggers a series of events that lead the Cooper family to the brink. Melissa Peterman guest stars.

Season 5, Episode 1 - One Bad Night and Chaos of Selfish Desires Airs October 7, 2021 at 8:00/7:00c on CBS Sheldon and Missy both run away from home, and Mary gets upsetting news about George Sr. Wallace Shawn and Melissa Peterman guest star.

Season 4, Episode 17 - A Black Hole Airs May 6, 2021 at 8:00/7:00c on CBS The Coopers discuss the possibilities of black holes and alternate universes when Dr. Sturgis comes over for dinner. Wallace Shawn and Wendie Malick guest star.

Season 4, Episode 16 - A Second Prodigy and the Hottest Tips for Pouty Lips Airs April 29, 2021 at 8:00/7:00c on CBS Sheldon finds himself at odds with Paige (Mckenna Grace) once again when she considers enrolling at East Texas Tech. Also, Mary seeks June’s (Reba McEntire) advice when looking for a change.

Season 4, Episode 13 - The Geezer Bus and a New Model for Education Airs April 8, 2021 at 8:00/7:00c on CBS Sheldon refuses to ride in a car after getting into an accident with Meemaw. Also, Missy uses their trauma to her advantage at school and Meemaw is forced to take the church shuttle while her car is in the shop.

Season 4, Episode 14 - Mitch's Son and the Unconditional Approval of a Government Agency Airs April 15, 2021 at 8:00/7:00c on CBS When the IRS accuses Sheldon of making a mistake, he’ll stop at nothing to prove them wrong. Also, Dale is forced to get a colonoscopy and tries to convince Meemaw to join him.

Season 4, Episode 7 - A Philosophy Class and Worms That Can Chase You Airs February 11, 2021 at 8:00/7:00c on CBS Sheldon’s first day of college is derailed by his new philosophy teacher, Professor Ericson (Melanie Lynskey). Also, Mary and Brenda (Melissa Peterman) live vicariously through Missy’s first day of middle school. Ed Begley, Jr. and Melanie Lynskey guest star.

Season 4, Episode 12 - A Box of Treasure and the Meemaw of Science Airs April 1, 2021 at 8:00/7:00c on CBS Sheldon, Dr. Linkletter and Meemaw team up on a science experiment. Also, Mary is jealous that Pastor Jeff and Brenda (Melissa Peterman) are spending time together, and Georgie has a new side hustle.

Season 4, Episode 11 - A Pager, a Club and a Cranky Bag of Wrinkles Airs March 11, 2021 at 8:00/7:00c on CBS Dr. Linkletter (Ed Begley, Jr.) pushes Sheldon to make friends with his fellow students at college. Also, Georgie gets a pager. Reba McEntire, Ed Begley, Jr. and Craig T. Nelson guest star.

Season 4, Episode 10 - Cowboy Aerobics and 473 Grease-Free Bolts Airs March 4, 2021 at 8:00/7:00c on CBS Sheldon campaigns to become Dr. Linkletter’s (Ed Begley, Jr.) lab assistant. Also, Georgie enlists the help of Mr. Lundy (Jason Alexander), the drama teacher, for a surprising business venture. Jason Alexander and Ed Begley, Jr. guest star.

Season 4, Episode 9 - Crappy Frozen Ice Cream and an Organ Grinder's Monkey Airs February 25, 2021 at 8:00/7:00c on CBS Sheldon and George Sr. dine with President Hagemeyer (Wendie Malick) and a university benefactor. Also, Georgie gives Missy some brotherly advice when Mary won’t let her go to the school dance, and Dale and June (Reba McEntire) convince Meemaw to attend their son’s wedding. Wendie Malick (Just Shoot Me!, Hot in Cleveland) guest stars. Craig T. Nelson and Reba McEntire return.

Season 4, Episode 8 - An Existential Crisis and a Bear That Makes Bubbles Airs February 18, 2021 at 8:00/7:00c on CBS Meemaw takes matters into her own hands when Sheldon's philosophy teacher, Professor Ericson (Melanie Lynskey), sends him into a tailspin. Also, George Sr. learns Georgie has been cutting class. Wallace Shawn, Ed Begley, Jr. and Melanie Lynskey guest star.

Season 4, Episode 6 - Freshman Orientation and the Inventor of the Zipper Airs January 21, 2021 at 8:00/7:00c on CBS College orientation does not go as Sheldon planned. Also, Mary is invited to a party when she’s mistaken for a university student, and George Sr. helps Pastor Jeff set up a children’s nursery. Wallace Shawn, Melissa Peterman and Wyatt McClure guest star.

Season 4, Episode 5 - A Musty Crypt and a Stick to Pee On Airs December 17, 2020 at 8:00/7:00c on CBS Dale and Meemaw work out relationship issues while playing Dungeons and Dragons with Sheldon and Missy. Also, Mary and George take a trip with Coach Wilkins (Doc Farrow) and his wife, and Georgie freaks out when his girlfriend thinks she’s pregnant. Craig T. Nelson guest stars as Dale.

Season 4, Episode 4 - Bible Camp and a Chariot of Love Airs December 3, 2020 at 8:00/7:00c on CBS Sheldon finds himself in a fierce competition with Paige when their mothers force them to attend Vacation Bible School. Also, George is furious after Georgie makes a questionable purchase. Craig T. Nelson and Mckenna Grace guest star.